How do we know that what we feel is “real?” Or maybe a bigger and more pressing question—what does “real” even mean? Or beyond even that question, does it matter, in the end, what in our lives was “real” and what was manufactured by substances, experiences, memories, or encounters? As much as medical technology has advanced, our understanding of depression and anxiety in particular continues to develop. The Effect gives us numerous viewpoints about both the advantages of medication as well as the creative possibilities inherent in non-neurotypical brains.